Circulating insulin-like growth factor-I and binding protein-3 and risk of prostate cancer
Identifieur interne : 00A049 ( Main/Exploration ); précédent : 00A048; suivant : 00A050Circulating insulin-like growth factor-I and binding protein-3 and risk of prostate cancer
Auteurs : Gianluca Severi [Australie] ; Howard A. Morris [Australie] ; Robert J. Maclnnis [Australie] ; Dallas R. English [Australie] ; Wayne D. Tilley [Australie] ; John L. Hopper [Australie] ; Peter Boyle [France] ; Graham G. Giles [Australie]Source :
- Cancer epidemiology, biomarkers & prevention [ 1055-9965 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
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Abstract
Some recent epidemiologic studies have failed to confirm positive associations between insulin-like growth factor-I (IGF-I) and the risk of prostate cancer observed in earlier studies but have reported suggestive evidence for a positive association between IGF-binding protein-3 (IGFBP-3) and prostate cancer risk, a result contradicting the earlier assumption that high levels of IGFBP-3 would be protective against prostate cancer. We tested the association between IGF-I and IGFBP-3 and prostate cancer risk by measuring the two peptides in plasma samples collected at baseline in a prospective cohort study of 17,049 men. We used a case-cohort design, including 524 cases diagnosed during a mean of 8.7 years follow-up and a randomly sampled subcohort of 1,826 men. The association between each peptide level and prostate cancer risk was tested using Cox models adjusted for country of birth and alcohol consumption. The risk of prostate cancer was not associated with baseline levels of IGF-I or the molar ratio IGF-I/IGFBP-3 (all odds ratios are between 0.82 and 1.08; Ptrend ≥ 0.2), whereas the risk increased with baseline levels of IGFBP-3 (Ptrend = 0.008), the hazard ratio (HR) associated with a doubling of the concentration of IGFBP-3 being 1.70 (95% confidence interval, 1.15-2.52). The HR for quartile 4 relative to quartile 1 of IGFBP-3 was 1.49 (95% confidence interval, 1.11-2.00). The HRs did not differ by tumor aggressiveness or age at onset (all Ps ≥ 0.4). In our study, high levels of IGFBP-3 but not IGF-I were associated with an increased risk of prostate cancer.
Affiliations:
- Australie, France
- Auvergne-Rhône-Alpes, Rhône-Alpes, Victoria (État)
- Lyon, Melbourne
- Université de Melbourne
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Maclnnis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cancer Epidemiology Centre, The Cancer Council Victoria</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Cancer Epidemiology Centre, The Cancer Council Victoria</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R." last="English">Dallas R. English</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cancer Epidemiology Centre, The Cancer Council Victoria</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Cancer Epidemiology Centre, The Cancer Council Victoria</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Tilley, Wayne D" sort="Tilley, Wayne D" uniqKey="Tilley W" first="Wayne D." last="Tilley">Wayne D. Tilley</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hanson Institute, Department of Medicine, University of Adelaide</s1><s2>Adelaide, South Australia</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Adelaide, South Australia</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Dame Roma Mitchell Cancer Research Laboratories, Department of Medicine, University of Adelaide</s1><s2>Adelaide, South Australia</s2><s3>AUS</s3><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Adelaide, South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Boyle, Peter" sort="Boyle, Peter" uniqKey="Boyle P" first="Peter" last="Boyle">Peter Boyle</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>IARC</s1><s2>Lyon</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cancer Epidemiology Centre, The Cancer Council Victoria</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Cancer Epidemiology Centre, The Cancer Council Victoria</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author></analytic><series><title level="j" type="main">Cancer epidemiology, biomarkers & prevention</title><title level="j" type="abbreviated">Cancer epidemiol. biomark. prev.</title><idno type="ISSN">1055-9965</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Cancer epidemiology, biomarkers & prevention</title><title level="j" type="abbreviated">Cancer epidemiol. biomark. prev.</title><idno type="ISSN">1055-9965</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Australia</term><term>Blood</term><term>Cancerology</term><term>Cohort study</term><term>Epidemiology</term><term>Human</term><term>Insulin like growth factor 1</term><term>Insulin-like growth factor binding protein-3</term><term>Nephrology</term><term>Prostate cancer</term><term>Risk factor</term><term>Urology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Facteur croissance IGF1</term><term>Sang</term><term>Facteur risque</term><term>Cancer prostate</term><term>Epidémiologie</term><term>Etude cohorte</term><term>Cancérologie</term><term>Australie</term><term>Homme</term><term>Urologie</term><term>Protéine liaison IGFBP3</term><term>Néphrologie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Australie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Some recent epidemiologic studies have failed to confirm positive associations between insulin-like growth factor-I (IGF-I) and the risk of prostate cancer observed in earlier studies but have reported suggestive evidence for a positive association between IGF-binding protein-3 (IGFBP-3) and prostate cancer risk, a result contradicting the earlier assumption that high levels of IGFBP-3 would be protective against prostate cancer. We tested the association between IGF-I and IGFBP-3 and prostate cancer risk by measuring the two peptides in plasma samples collected at baseline in a prospective cohort study of 17,049 men. We used a case-cohort design, including 524 cases diagnosed during a mean of 8.7 years follow-up and a randomly sampled subcohort of 1,826 men. The association between each peptide level and prostate cancer risk was tested using Cox models adjusted for country of birth and alcohol consumption. The risk of prostate cancer was not associated with baseline levels of IGF-I or the molar ratio IGF-I/IGFBP-3 (all odds ratios are between 0.82 and 1.08; P<sub>trend</sub> ≥ 0.2), whereas the risk increased with baseline levels of IGFBP-3 (P<sub>trend</sub> = 0.008), the hazard ratio (HR) associated with a doubling of the concentration of IGFBP-3 being 1.70 (95% confidence interval, 1.15-2.52). The HR for quartile 4 relative to quartile 1 of IGFBP-3 was 1.49 (95% confidence interval, 1.11-2.00). The HRs did not differ by tumor aggressiveness or age at onset (all Ps ≥ 0.4). In our study, high levels of IGFBP-3 but not IGF-I were associated with an increased risk of prostate cancer.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li><li>Victoria (État)</li></region><settlement><li>Lyon</li><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></noRegion><name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R." last="English">Dallas R. English</name><name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R." last="English">Dallas R. English</name><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><name sortKey="Maclnnis, Robert J" sort="Maclnnis, Robert J" uniqKey="Maclnnis R" first="Robert J." last="Maclnnis">Robert J. Maclnnis</name><name sortKey="Maclnnis, Robert J" sort="Maclnnis, Robert J" uniqKey="Maclnnis R" first="Robert J." last="Maclnnis">Robert J. Maclnnis</name><name sortKey="Morris, Howard A" sort="Morris, Howard A" uniqKey="Morris H" first="Howard A." last="Morris">Howard A. Morris</name><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><name sortKey="Tilley, Wayne D" sort="Tilley, Wayne D" uniqKey="Tilley W" first="Wayne D." last="Tilley">Wayne D. Tilley</name><name sortKey="Tilley, Wayne D" sort="Tilley, Wayne D" uniqKey="Tilley W" first="Wayne D." last="Tilley">Wayne D. Tilley</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Boyle, Peter" sort="Boyle, Peter" uniqKey="Boyle P" first="Peter" last="Boyle">Peter Boyle</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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